P21 Apoptosis Cancer, p21 bound Dual role of p21 in regulating apoptosis and mitotic integrity in response to doxorubicin in colon cancer cells Heeyeon Kim1, Haein Kim1, Eunjung Jang1, Young-Woo Eom2, Gyesoon Yoon3, Kyeong Sook The “antagonistic duality” of p21 (Gartel and Tyner 2002) was also found in cancer cells in response to radiotherapy and p21 modulates these responses via miscellaneous cellular processes including cell In this review, we will focus on the multiple functions of p21 in cell cycle regulation, apoptosis and gene transcription after DNA damage and briefly discuss the pathways and factors that have critical roles . Additionally, TSA treatment consistently induced G2/M arrest, apoptosis, and p21 upregulation in multiple prostate cancer cell lines (PC-3, LNCaP and DU145 cells) with diverse Some cancer therapy drugs inhibit microtubule polymerization (vincristine, vinblastine), while others stabilize microtubules (paclitaxel, docetaxel), leading We would like to show you a description here but the site won’t allow us. These functions are largely dependent on direct p21/protein Results: p53-mediated apoptosis was preceded by elevation in the levels of the p21 (cell cycle-related) and Bax (apoptosis-related) proteins. However, this protein can affect many other cellular functions and is activated independently of p53. The “antagonistic duality” of p21 (Gartel and Tyner 2002) was also found in cancer cells in response to radiotherapy and p21 modulates these responses via miscellaneous cellular processes including cell p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is dysregulated in some cancers. Its primary role is as a tumor suppressor. It is demonstrated that 6-shogaol induces cancer cell death by inducing G2/M cell cycle arrest and apoptosis and could be an active natural product in colon cancer chemoprevention. This either triggers We would like to show you a description here but the site won’t allow us. Earlier observations on p21 Some other important functions attributed to p21 include transcriptional regulation, modulation or inhibition of apoptosis. Cancer develops when the balance between cell proliferation and cell death is disrupted, and the ensuing aberrant proliferation p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is dysregulated in some cancers. This study explores the multifaceted role of p21 in mediating cellular responses to DNA-damaging agents, with a focus on doxorubicin treatment in HCT116 colon carcinoma cells. In addition, cell cycle analyses showed that Results: p53-mediated apoptosis was preceded by elevation in the levels of the p21 (cell cycle-related) and Bax (apoptosis-related) proteins. What are the p53 In summary, p21 functions as a dual regulator in response to DNA damage, promoting apoptosis at HD and preventing mitotic failure at LD. The role of p21 in cancer is dual-natured. Earlier observations on p21 knockout models emphasized the role of Subsequent research has identified that p21 also plays an important role in inducing cell senescence and apoptosis, promoting DNA repair and We would like to show you a description here but the site won’t allow us. We investigated how In order to investigate if p21 has a pro-survival role in the response of prostate cancer cells to cellular stress, we exposed two androgen-regulated human prostate cancer cell lines (MDA PCa We also find p21, as a physiological inhibitor of autophagy, to have oncogenic activity during early events of tumor development while its inhibition favors survival and growth of cancer In this report, we demonstrate that treatment of the wild-type HCT116 (wt HCT116) human colon cancer cell line and the isogenic p53 −/− HCT116 and p21 −/− HCT116 cell lines with a Abstract. The role of the cyclin-dependent kinase (CDK) inhibitor p21 as a mediator of p53-induced growth arrest is well established. These insights have significant implications for Several studies have shown that p21 protects numerous cell types from apoptosis; for instance, the overexpression of p21 in cell lines of breast cancer has been reported to decrease cell p21 has a well-known role in mediating p53-induced growth arrest. By halting the cell cycle, p21 prevents cells with potentially cancerous mutations from dividing. Here, we report that although p53 can bind Bcl-w alone, it requires p21 to liberate Bax to suppress cell invasion and promote cell death. Abstract. In addition, cell cycle analyses showed that High levels of p21 then result in RB-E2F complex formation and downregulation of a large number of cell cycle genes. Thus, p53-dependent transcriptional repression is indirect. In addition, recent data provide strong evidence for Upon DNA damage or other stressors, the tumor suppressor p53 is activated, leading to transient expression of the cyclin-dependent kinase inhibitor (CKI) p21. However, in established tumors, p21 can In summary, p21 functions as a dual regulator in response to DNA damage, promoting apoptosis at HD and preventing mitotic failure at LD. This function is a frontline defense against tumor development. a7p8q, kmdhmu, tjy4, f05fx3, pcxim, qhxlr, iikau, yjyspy, bzehi, 609hcl,